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Ketofol: Are you ready for change?

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The ideal pharmacologic agent for procedural sedation and analgesia would provide an adequate level of sedation while minimizing pain and anxiety, maximizing amnesia, minimizing the potential for adverse drug-related events, controlling behavior, and maintaining a stable cardiovascular and respiratory status. Sound like the Holy Grail of procedural sedation?

Well…many studies have shown that in the end…Ketofol for ED procedural sedation does not result in a reduced incidence of adverse respiratory events compared with propofol alone. Induction time, efficacy, and sedation time were similar; however, sedation depth appeared to be more consistent with ketofol.

 

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