Home / Pharmacology / Ketofol: Are you ready for change?

Ketofol: Are you ready for change?








The ideal pharmacologic agent for procedural sedation and analgesia would provide an adequate level of sedation while minimizing pain and anxiety, maximizing amnesia, minimizing the potential for adverse drug-related events, controlling behavior, and maintaining a stable cardiovascular and respiratory status. Sound like the Holy Grail of procedural sedation?

Well…many studies have shown that in the end…Ketofol for ED procedural sedation does not result in a reduced incidence of adverse respiratory events compared with propofol alone. Induction time, efficacy, and sedation time were similar; however, sedation depth appeared to be more consistent with ketofol.


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